EFFECT OF CELL-FREE DNA SCREENING VS DIRECT INVASIVE DIAGNOSIS ON MISCARRIAGE RATES IN WOMEN WITH PREGNANCIES AT HIGH RISK OF TRISOMY 21. A RANDOMIZED CLINICAL TRIAL

Effect of Cell-Free DNA Screening vs Direct Invasive Diagnosis on Miscarriage Rates in Women With Pregnancies at High Risk of Trisomy 21. A Randomized Clinical Trial

Valérie Malan, MD, PhD; Laurence Bussières, PhD; Norbert Winer, MD, PhD; et al

JAMA. 2018;320(6):557 565. doi:10.1001/jama.2018.9396

Question: Does performing cell-free DNA testing on women with pregnancies at high risk of trisomy 21, followed by invasive testing only if cell-free DNA test results are positive, reduce the rate of miscarriage compared with immédiate invasive testing?